What Are Polynucleotides?
Polynucleotides are biostimulating molecules derived from purified DNA fragments, typically sourced from salmon or trout. These fragments are not active genetic material but act as potent stimulators for:
- Cell regeneration
- Tissue repair
- Hydration
- Collagen and elastin production
Unlike traditional filler which volumises, polynucleotides improve the quality and function of your skin—enhancing texture, tone, elasticity, and resilience.
How Do They Work?
Think of polynucleotides as cell whisperers. Once injected into the skin, they:
- Trigger fibroblast activity, increasing collagen and elastin.
- Neutralise free radicals, reducing oxidative stress and inflammation.
- Improve skin hydration by supporting the extracellular matrix.
- Enhance microcirculation, resulting in healthier, more vibrant skin.
The result? Firmer, smoother, more luminous skin—without altering your facial structure.
How Do They Compare to Fillers and Profhilo?
Many patients ask whether polynucleotides are similar to dermal fillers or Profhilo. The answer is: they’re in a category of their own. Here’s how they compare:
| Feature | Polynucleotides | Profhilo | Dermal Filler |
| Main Function | Skin regeneration and repair | Hydration & mild collagen stimulation | Volume restoration & contouring |
| Composition | Purified DNA fragments (salmon/trout) | Stabilised hyaluronic acid | Cross-linked hyaluronic acid |
| Primary Benefits | Improves texture, reduces inflammation, hydrates | Hydrates and firms with subtle glow | Lifts and sculpts facial features |
| Treatment Areas | Under-eyes, face, neck, hand, scars | Face, neck, hands, body | Face and body |
| Volume Effect | No – improves skin quality | Mild plumping | Strong volumising effect |
| Ideal For | Crepey skin, scarring, redness | Dehydrated, lax skin | Facial volume loss, fine lines |
| Onset of Results | Visible at 3–6 weeks, improves over time | Glow in 1–2 weeks, best at 4–6 weeks | Immediate volume, peak at 1–2 weeks |
| Clinical Style | Biostimulatory – skin-first approach | Hydrating injectable | Volumising injectable |
Who Is It For?
Polynucleotide therapy is ideal for patients who are:
- Seeing early signs of ageing (fine lines, loss of glow)
- Dealing with crepey under-eye skin or sun damage
- Experiencing scarring or post-acne pigmentation
- Suffering from redness, dullness, or dehydrated skin
- Seeking natural-looking results without adding volume
It’s also a fantastic treatment for those looking to repair and future-proof their skin after laser or microneedling treatments.
Key Benefits at a Glance
- Improves skin elasticity and firmness
- Reduces fine lines and crepiness, especially around the eyes
- Deeply hydrates and restores skin vitality
- Minimises redness and inflammation
- Suitable for sensitive and acne-prone skin
- Safe on all skin types and tones
Why We Love It at Fitzrovia Clinic
At Fitzrovia Clinic, we value results with integrity. Polynucleotides fit seamlessly into our personalised approach—whether paired with LaseMD Ultra, microneedling, or as part of our Fitzrovia Formula for long-term skin health.
They work beautifully in delicate areas—under the eyes, neck, and décolletage—where traditional treatments may fall short. Patients love the subtle radiance, long-term improvement, and virtually no downtime.
What Is Treatment Like?
- Series of small injections using a fine needle or cannula
- Typically performed in 2–3 sessions, spaced 3–4 weeks apart
- Mild swelling or redness may occur, but most return to normal activity the same day
- Results become more visible after 3–6 weeks, with continued improvement over months
Frequently Asked Questions
Is it a filler?
No. Polynucleotides don’t add volume—they improve the quality of existing tissue.
Is it suitable for under-eye treatment?
Yes. It’s one of the most effective and safe options for treating under-eye fine lines, thinning skin, and pigmentation.
Can it be combined with other treatments?
Absolutely. We often combine it with light resurfacing lasers, LED therapy, or Profhilo depending on your goals.
Why Now?
In an era where patients are prioritising skin health over surface fixes, polynucleotides are a major leap forward. Backed by clinical evidence and embraced across Europe and Asia, they represent a new frontier in regenerative aesthetics—and they’re here to stay.
Available at Fitzrovia Clinic
If you’re seeking a subtle, skin-first approach to rejuvenation, polynucleotides may be the
treatment you didn’t know you were looking for.
Book a consultation with one of our doctors at Fitzrovia Clinic to see if it’s right for you.
